Nutr Res Pract.  2010 Apr;4(2):106-113.

Effects of corn gluten hydrolyzates, branched chain amino acids, and leucine on body weight reduction in obese rats induced by a high fat diet

• Bong HY
• Kim JY
• Jeong HI
• Moon MS
• Kim J
• Kwon O

Abstract

In this study, we compared corn gluten hydrolyzates, BCAAs, and leucine for their effects on body weight reduction in high fat-induced obese rats in order to determine the major active components in the corn gluten hydrolyzates. After obesity was induced for 13 weeks with high fat diet, the overweight-induced SD rats (n = 64) were stratified according to body weight, randomly blocked into eight treatments, and raised for 8 weeks. Four groups were changed to a normal diet and the other groups remained on the high fat diet. Each of the groups within both diets was fed either casein, corn gluten hydrolyzates, leucine, or branched chain amino acids, respectively. Daily food intake, body weight gain, and food efficiency ratio were significantly lower in the corn gluten hydrolyzate groups compared to the other groups, regardless of the high fat diet or normal fat diet. The rats fed the corn gluten hydrolyzates diet had the lowest perirenal fat pad weights whereas muscle weight was significantly increased in the corn gluten hydrolyzates groups. Plasma triglyceride, hepatic total lipid, and total cholesterol contents were significantly reduced in the corn gluten hydrolyzates groups. Other lipid profile measurements were not significantly changed. Plasma triglyceride and hepatic total lipid were also significantly reduced in the BCAA and leucine groups. Leptin levels were significantly lower and adiponectin was significantly higher in the corn gluten hydrolyzates groups. Fasting blood glucose, insulin, C-peptide, and HOMA-IR levels were also significantly reduced in the corn gluten hydrozylates groups, regardless of fat level.

Keyword

Corn gluten hydrolyzates; branched chain amino acids; leucine; body weight; insulin resistance

MeSH Terms

Adiponectin
Adipose Tissue
Amino Acids
Animals
Blood Glucose
Body Weight
C-Peptide
Caseins
Cholesterol
Diet
Diet, High-Fat
Eating
Fasting
Glutens
Insulin
Insulin Resistance
Leptin
Leucine
Muscles
Obesity
Plasma
Rats
Weights and Measures
Zea mays
Adiponectin
Amino Acids
Blood Glucose
C-Peptide
Caseins
Cholesterol
Glutens
Insulin
Leptin
Leucine

Figure

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  Fig. 1 The changes of body weight (A) and food intake (B) during 8 weeks treatment of corn gluten hydrolyzates, BCAAs, and leucine. Because of scarifying and collecting metabolic samples, food intake was measured for 7 weeks. Values are expressed as means ± SE shown by vertical bars. Statistical significance was calculated by one-way ANOVA. Comparison were done among different groups (*P < 0.05) (○ casein as control, • corn gluten hydrolyzates, ▴ BCAAs, ▪ Leucine).

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