Nutr Res Pract.  2009 Jun;3(2):108-113.

Effects of taurine supplementation on bone mineral density in ovariectomized rats fed calcium deficient diet

• Choi MJ

Abstract

Taurine supplementation has been shown to have a beneficial effect on femur bone mineral content in ovariectomized rats. It therefore seemed desirable to find out whether the beneficial effect of taurine on ovariectomized rats fed calcium deficient diet could also be reproduced. Forty female Sprague-Dawley rats were divided into two groups. One group was OVX and the other group received sham operation (SHAM), and received either control diet or a taurine supplemented diet for 6 weeks. All rats were fed on calcium deficient diet (AIN-93: 50% level of calcium) and deionized water. Bone mineral density (BMD) and bone mineral content (BMC) were measured in spine and femur. The serum and urine concentrations of calcium and phosphorus were determined. Bone formation was measured by serum osteocalcin and alkaline phosphatase (ALP) concentrations. Bone resorption rate was measured by deoxypyridinoline (DPD) crosslinks immunoassay and corrected for creatinine. Urinary calcium and phosphorus excretion, osteocalcin in blood and cross link value were not significantly different among the groups. Within the OVX group, the taurine supplemented group had not higher femur bone mineral content than the control group. This study established the need for a study on the taurine effect on bone with different calcium levels.

Keyword

Taurine; OVX; BMD; calcium deficient diet

MeSH Terms

Alkaline Phosphatase
Aluminum Hydroxide
Amino Acids
Animals
Bone Density
Bone Resorption
Calcium
Carbonates
Creatinine
Diet
Female
Femur
Humans
Immunoassay
Osteocalcin
Osteogenesis
Phosphorus
Rats
Rats, Sprague-Dawley
Salicylamides
Spine
Taurine
Water
Alkaline Phosphatase
Aluminum Hydroxide
Amino Acids
Calcium
Carbonates
Creatinine
Osteocalcin
Phosphorus
Salicylamides
Taurine
Water

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