Nutr Res Pract.  2007 Mar;1(1):65-69.

The associations between serum leptin, adiponectin and intercellular adhesion molecule-1 in hypercholesterolemic patients

• Park E
• Shin MJ
• Chung N

Abstract

We examined the associations between adiponectin or leptin and serum ICAM-1 levels in seventy-six hypercholesterolemic patients (mean age 59 yrs, 25 males and 51 females, LDL-cholesterol>=130mg/dL at screening). Blood lipid profiles and HOMA-IR derived from fasting glucose and insulin concentrations were determined. Serum levels of adiponectin, leptin and ICAM-1 were analyzed using ELISA. The results showed that serum levels of leptin were positively associated with serum levels of ICAM-1 independent of age, sex and BMI (r =0.392, p<0.001). Serum levels of adiponectin were negatively associated with serum levels of ICAM-1 independent of age, sex and BMI (r =-0.343, p<0.005). Stepwise multiple linear regression analysis showed that serum leptin was an independent factor to be associated with serum ICAM-1 levels after adjusting for age, sex, BMI, alcohol intake, smoking status, blood lipids such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol and HOMA-IR (p<0.001). With respect to adiponectin, its association with serum ICAM-1 was attenuated but still significant when further adjustments were made for age, sex, BMI, alcohol intake, smoking status, blood lipids such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol and HOMA-IR (p<0.005). In conclusion, this study suggests that adiponectin and leptin are associated with endothelial derived inflammation.

Keyword

Leptin; adiponectin; ICAM-1; adipokine; hypercholesterolemia

MeSH Terms

Adipokines
Adiponectin*
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Enzyme-Linked Immunosorbent Assay
Fasting
Female
Glucose
Humans
Hypercholesterolemia
Inflammation
Insulin
Intercellular Adhesion Molecule-1*
Leptin*
Linear Models
Male
Smoke
Smoking
Triglycerides
Adipokines
Adiponectin
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Glucose
Insulin
Intercellular Adhesion Molecule-1
Leptin
Smoke

Figure

• 

  Fig. 1 Correlations between leptin or adiponectin and Serum ICAM-1 levels of the subjects

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