Nucl Med Mol Imaging.  2015 Mar;49(1):3-10. 10.1007/s13139-014-0309-x.

In Vivo Cell Tracking with Bioluminescence Imaging

• Kim JE
• Kalimuthu
• Ahn BC

• KMID: 2313239
• DOI: http://doi.org/10.1007/s13139-014-0309-x

Abstract

Molecular imaging is a fast growing biomedical research that allows the visual representation, characterization and quantification of biological processes at the cellular and subcellular levels within intact living organisms. In vivo tracking of cells is an indispensable technology for development and optimization of cell therapy for replacement or renewal of damaged or diseased tissue using transplanted cells, often autologous cells. With outstanding advantages of bioluminescence imaging, the imaging approach is most commonly applied for in vivo monitoring of transplanted stem cells or immune cells in order to assess viability of administered cells with therapeutic efficacy in preclinical small animal models. In this review, a general overview of bioluminescence is provided and recent updates of in vivo cell tracking using the bioluminescence signal are discussed.

Keyword

Optical imaging; Bioluminescence; Cell tracking; In vivo imaging; Cell therapy

MeSH Terms

Biological Processes
Cell Tracking*
Cell- and Tissue-Based Therapy
Models, Animal
Molecular Imaging
Optical Imaging
Stem Cells