Mycobiology.
2007 Mar;35(1):11-15.
The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells
- Affiliations
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- 1Institute of Food & Culture R&D Center, Pulmuone Co., Ltd., Seoul 120-600, Korea. hcha@pulmuone.co.kr
- 2Division of Life Sciences, Kyungnam University, Masan, Kyungnam, Korea.
- 3Department of Biodynamics, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa-machi, Kanazawa, Ishikawa 920-1181, Japan.
- 4Organization for Frontier Research, Hokuriku University, Kanagawa-machi, Kanazawa, Ishikawa 920-1181, Japan.
Abstract
- We examined the neuroprotective and neurotrophic effects of Tremella fuciformis. The neurotrophic effects of the hot water extract of T. fuciformis was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells. The hot water extract of T. fuciformis promoted neurite outgrowth in PC12h cells in this study, superior to other natural substances which was reported previously. When cells were treated with the hot water extract of T. fuciformis prior to beta-amyloid peptide treatment (active domain of A peptide 25~35 treated), toxicity was significantly diminished (p<0.01). These results suggest that T. fuciformis might potentially be used as a precautionary agent in neurodegenerative disease, such as Alzheimer's disease, etc.
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