Lab Anim Res.  2016 Mar;32(1):74-77. 10.5625/lar.2016.32.1.74.

Pathomorphological features of calcinosis circumscripta in a dog

Affiliations
  • 1College of Veterinary Medicine, Kyungpook National University, Daegu, Korea. jeongks@knu.ac.kr
  • 2Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Korea.

Abstract

A 19-month-old male German shepherd dog was presented with a hindlimb footpad mass. The mass was excised and histopathology was performed. Grossly, the cut section of the mass had multiple well-circumscribed nodules with a chalky appearance. Histopathologically, basophilic-stained calcium deposits of various sizes were distributed from dermis to subcutis, surrounded by epithelioid cells, multinucleated giant cells, and reactive fibroblasts. Myxoid metaplasia, calcium deposits in hair follicles, and psammoma-like bodies were also found. These histopathologic observations will greatly help to understand the pathogenesis of calcinosis circumscripta.

Keyword

Calcinosis circumscripta; histopathologic diagnosis; myxoid change; Psammoma-like body

MeSH Terms

Animals
Calcinosis*
Calcium
Dermis
Dogs*
Epithelioid Cells
Fibroblasts
Giant Cells
Hair Follicle
Hindlimb
Humans
Infant
Male
Metaplasia
Calcium
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