Lab Anim Res.  2010 Jun;26(2):215-218. 10.5625/lar.2010.26.2.215.

A Tumoral Calcinosis Case in a Beagle Dog

• Shin SK
• Kim G
• Chang D
• Na KJ
• Ahn B

• KMID: 2312068
• DOI: http://doi.org/10.5625/lar.2010.26.2.215

Abstract

We describe a case of tumoral calcinosis in a 13-month-old female Beagle dog presenting for surgical removal of a 4x3x3 cm mass in the soft tissues of the medial right shoulder joint. On radiologic examination, the mass showed increased radiopacity. Blood analysis data indicated chronic renal failure with hyperphosphatemia and hypercalcemia. Grossly, the mass was irregular, round and multilocular, with hard consistency. Histologically, there were many variable-sized loculi surrounded by capsule and interstitial connective tissues were generated among the loculi. Inflammatory cells, fibroblasts, fibrocytes and multinucleated giant cells were present at the margins of the loculi. Most of the loculi were filled with calcium or chalky material. To our knowledge, this is the first case of tumoral calcinosis in Korea.

Keyword

Beagle dog; case report; tumoral calcinosis

MeSH Terms

Animals
Calcinosis
Calcium
Connective Tissue
Dogs
Female
Fibroblasts
Giant Cells
Humans
Hypercalcemia
Hyperphosphatemia
Infant
Kidney Failure, Chronic
Korea
Shoulder Joint
Calcium

Figure

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  Figure 1. Radiographic appearance. Ventrodorsal view of right shoulder joint. Note the 3.7×2.7 cm mass with increased radiopacity in soft tissue of medial right shoulder joint. The mass shows round shape with irregular margin.

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  Figure 2. Gross lesion of the mass. The mass of 4×4×3 cm was irregular and hard. The mass has multiple lobes with variable sizes.

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  Figure 3. Histologic lesion of tumoral calcinosis. The loculi were surrounded by the interstitial tissues. Note the calcium or chalky material in the lumen of the locule (A). Multinucleated giant cells, histiocytes, and fibroblasts form a cellular palisading along the margins of the locule (B). H & E stain.

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