Lab Anim Res.  2015 Dec;31(4):204-208. 10.5625/lar.2015.31.4.204.

Radiation-induced eosinophilic, polymorphic, and pruritic eruption in a pig skin model

Affiliations
  • 1Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul, Korea. sslee@kcch.re.kr, jskim@dirams.re.kr
  • 2Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan, Korea.

Abstract

Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) can occur in cancer patients after irradiation. In this study, we characterized the clinical and histopathological features of pig skin that developed widespread polymorphic and pruritic skin lesions following localized 50 Gy gamma-irradiation. The pigs developed pruritus 5-7 weeks after irradiation, and infiltration of the dermis by eosinophils was detected 4-7 weeks after irradiation. The irradiated animals also showed transiently increased numbers of peripheral eosinophils 5-7 weeks after treatment. Irradiation induced desquamation after 2-4 weeks, which and the desquamation gradually resolved after 7 weeks. These pathological changes correspond to those seen in irradiated human skin, indicating that this model could be useful for elucidating the pathogenesis of EPPER and for developing therapeutic and prophylactic methods.

Keyword

Radiation; pig; skin; eosinophil; pruritis

MeSH Terms

Animals
Dermis
Eosinophils*
Humans
Pruritus
Radiotherapy
Skin*
Swine
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