Korean J Urol.  2009 Feb;50(2):148-153.

Comparison of the Efficacy of a Terpene Mixture and Alpha-Blocker for Treatment of Category III Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Prospective Study

• Cha WH
• Kim KH
• Seo YJ

Abstract

PURPOSE
The aim of this study was to evaluate the efficacy of a terpene mixture compared with alpha-blocker in patients with chronic pelvic pain syndrome (CPPS).
MATERIALS AND METHODS
Patients diagnosed with CPPS were included in this study. The patients were randomly placed into three groups. Group 1 was treated with levofloxacin alone (36 patients), group 2 was treated with levofloxacin and alfuzosin (33 patients), and group 3 was treated with levofloxacin and terpene mixture (34 patients) for 8 weeks. The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was evaluated in patients in each group at the beginning of the study and after 8 weeks of treatment.
RESULTS
Pain domain, urinary domain, quality of life domain, and total score on the NIH-CPSI were not significantly different at the initial visit. After treatment with each medication, improvements on the pain domain and total score of the NIH-CPSI were better in group 3 than in group 1 or group 2 (p<0.05). Improvement on the urinary domain of the NIH-CPSI was better in group 2 than in group 1 or group 3 (p=0.014). Changes in the quality of life domain of the NIH-CPSI were not significant among the three groups.
CONCLUSIONS
This study suggests that the terpene mixture and alpha-blockers may have significant benefit for symptomatic relief, especially in the pain and urinary domains, respectively.

Keyword

Pelvic pain; Adrenergic alpha-antagonists; Terpenes

MeSH Terms

Adrenergic alpha-Antagonists
Humans
National Institutes of Health (U.S.)
Ofloxacin
Pelvic Pain
Prospective Studies
Prostatitis
Quality of Life
Quinazolines
Terpenes
Adrenergic alpha-Antagonists
Ofloxacin
Quinazolines
Terpenes

Figure

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  Fig. 1 Mean value of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) pain domain score (potential of 21 points) at the beginning of the study and after 8 weeks of treatment in each group.

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  Fig. 2 Mean value of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) urinary domain score (potential of 10 points) at the beginning of the study and after 8 weeks of treatment in each group.

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  Fig. 3 Mean value of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) quality of life domain score (potential of 12 points) at the beginning of the study and after 8 weeks of treatment in each group.

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  Fig. 4 Mean value of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) total score (potential of 43 points) at the beginning of the study and after 8 weeks of treatment in each group.

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