Kosin Med J.  2014 Dec;29(2):93-98. 10.7180/kmj.2014.29.2.93.

An overview of the pathogenic mechanisms of autoimmune thyroid disorders

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Konyang University, Daejeon, Korea.

Abstract


Objectives
, recent epidemiologic studies in humans suggest an increased prevalence of thyroiditis associated with the excessive administration of iodine. More than three times of recommended daily intake of iodine was observed among people in North America. These people generally presented higher level of anti-thyroglobulin antibody, anti-thyroperoxidase antibody, serum thyroid-stimulating hormone and exacerbation of lymphocytic infiltration in thyroid, which indicated the overconsumption of iodine could induce hypothyroidism and enhance the autoimmune response. However, the precise mechanism of excessive iodine intake induced autoimmune thyroid disease remains largely unknown. Over half a century has elapsed since the 1956 identification of thyroglobulin antibodies and the devising of the first experimental model of autoimmune thyroiditis. Since then an incredible amount of experimental work has led to an ever deeper understanding of the nature of thyroid auto-antigens, the main immune mechanisms responsible for Hashimoto's thyroiditis and graves' disease, their genetics, and therir environmental risk factor. Yet, in the majority of genetically predisposed people the individual trigger of thyroid autoimmunity remains obscure. Similarly, effective prevention strategies still remain to be established and, hopefully, will be the target of future studies.

Keyword

Autoimmune; Pathogenic mechanism; Thyroid disorders

MeSH Terms

Antibodies
Autoimmunity
Genetics
Graves Disease
Humans
Hypothyroidism
Iodine
Models, Theoretical
North America
Prevalence
Recommended Dietary Allowances
Risk Factors
Thyroglobulin
Thyroid Diseases
Thyroid Gland*
Thyroiditis
Thyroiditis, Autoimmune
Thyrotropin
Antibodies
Iodine
Thyroglobulin
Thyrotropin

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