Korean J Psychosom Med.  2016 Dec;24(2):227-235. 10.0000/kjpm.2016.24.2.227.

Association of Cognitive Dysfunction with Thyroid Autoantibody

• Han DK
• Cheon JS
• Choi YS
• Kim HC
• Oh BH

• KMID: 2369158
• DOI: http://doi.org/10.0000/kjpm.2016.24.2.227

Abstract

OBJECTIVES
The aims of this study were to know the frequency of cognitive dysfunction among patients with autoimmune thyroid disorders, and to reveal influencing factors on it, especially to clarify association with autoimmune thyroid antibodies.
METHODS
From sixty-five female patients with autoimmune thyroid disorders, demographic data were obtained by structured interview. Their cognitive funtions were measured using the MMSE-K and the MoCA-K tests. Depression was evaluated by the K-HDRS.
RESULTS
1) Among patients with autoimmune thyroid disorders, 7.69% of them were below 24 on the MMSE-K, while 10.77% were below 22 on the MoCA-K. The frequency of cognitive deficit was not significantly different according to having positivity to antimicrosomal antibodies or not. 2) The antimicrosomal antibody-positive patients had significantly higher antithyroglobulin antibody titers, antimicrosomal antibody titers, and TSH concentration, while had significantly lower free T4 levels(p<0.05, respectively). 3) The total scores of the MMSE-K and the MoCA-K had significant correlation with age, marital status, antithyroglobulin antibody titers and K-HDRS(p<0.05, respectively). 4) The regression analysis revealed that variables such as age, education, autoimmune thyroid antibodies, thyroid function and depression did not influence on cognitive function of patients with autoimmune thyroid disorders.
CONCLUSIONS
Our results could not support that cognitive function of patients with autoimmune thyroid disorders had correlation with autoimmune thyroid antibodies.

Keyword

Autoimmune thyroid disorder; Cognitive dysfunction; Thyroid autoantibody; Positivity to antimicrosomal antibody; Depression; Thyroid function

MeSH Terms

Antibodies
Cognition
Cognition Disorders
Depression
Education
Female
Humans
Marital Status
Thyroid Gland*
Antibodies