Korean J Nephrol.  2005 Sep;24(5):832-837.

A Case of Microscopic Polyangiitis Associated with Paranasal Sinusitis and Pulmonary Hemorrhage

• Kim HK
• Shin HS
• Jung YS
• Ko JH
• Oak CH
• Jang TW
• Rim H
• Jung MH

Abstract

Microscopic polyangiitis is a systemic small-vessel vasculitis primarily associated with necrotizing glomerulonephritis and pulmonary capillaritis. This disease is determined by clinical manifestation, ANCA, and involved organ or renal biopsy. We describe a 49-year-old female presenting with chronic postnasal drip, progressive dyspnea and abrupt hemoptysis. Her serum p-ANCA was postitive, but c- ANCA was negative. Her chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed crescentic glomerulonephritis. She was diagnosed as having an ANCA-associated vasculitis, and more specifically, a microscopic polyangiitis accompanied with paranasal sinusitis. She was treated with intravenous methylprednisolone pulse therapy, followed by prednisolone and cyclophosphamide per oral tablets. She showed rapid progression of renal failure and died from sepsis after 2 months of treatment.

Keyword

Microscopic polyangiitis; Perinuclear antineutrophil cytoplasmic antibodies; Vasculitis; Pulmonary hemorrhage; Sinusitis

MeSH Terms

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Antibodies, Antineutrophil Cytoplasmic
Biopsy
Cyclophosphamide
Dyspnea
Female
Glomerulonephritis
Hemoptysis
Hemorrhage*
Humans
Methylprednisolone
Microscopic Polyangiitis*
Middle Aged
Prednisolone
Renal Insufficiency
Sepsis
Sinusitis*
Tablets
Thorax
Tomography, X-Ray Computed
Vasculitis
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide
Methylprednisolone
Prednisolone
Tablets