Korean J Med.  1998 Jun;54(6):833-839.

Systemic Lupus Erythematosus-like paraneoplastic syndrome associated with lung cancer

• Lee YJ
• Shin KC
• Kang SW
• Han CW
• Song YW

Abstract

Systemic lupus erythematosus (SLE) has been described very rarely in association with underlying malignancy. We experienced a 68-year-old male with systemic erythematosus lupus associated with squamous cell lung cancer. He had radiation therapy as a primary treatment modality. Ten months after the radiation therapy, he suffered from intermittent fever, myalgia, multiple arthralgia, dry cough, and dyspnea. He had leukocytosis and lymphopenia. Anti-nuclear antibody was positive. He had bilateral pleural effusion, pericardial effusion, and proteinuria (2405 mg/day). He had peripheral neuropathy with lower extremity weakness. There was no evidence of recurrence of lung cancer. He was treated with naproxen (1 gm/day) with symptomatic improvement. We describe a clinical course of paraneoplastic SLE in patient with lung cancer, and review the literatures.

Keyword

Systemic lupus erythematosus; Lung cancer; Paraneoplastic syndrome

MeSH Terms

Aged
Arthralgia
Cough
Dyspnea
Fever
Humans
Leukocytosis
Lower Extremity
Lung Neoplasms*
Lung*
Lupus Erythematosus, Systemic
Lymphopenia
Male
Myalgia
Naproxen
Paraneoplastic Syndromes*
Pericardial Effusion
Peripheral Nervous System Diseases
Pleural Effusion
Proteinuria
Recurrence
Naproxen