Korean J Med.  2000 Oct;59(4):438-441.

A case of malignant acanthosis nigricans associated with gastric adenocarcinoma

• Shim JK
• Kim MH
• Ha YJ
• Jun SG
• Kwon TK
• Kim HS
• Lee JH
• Yang YS

Abstract

The new onset of acanthosis nigricans in an adult-especially when the lesions appear on mucosal membranes such as the lips, periocular areas, and anus-may be indicative of an underlying tumor. Adenocarcinoma of the gastrointestinal tract is the most common malignancy-most often cancer of the stomach. A 72 years old female had disseminated, symmetrically distributed, brownish black pigmentation and papillary hypertrophy on the intertriginous and flexural areas for 12 months, and gastric adenocarcinoma was confirmed during the evaluation of internal malignancy. The cutaneous finding of acanthosis nigricans was a significant cutaneous marker of internal malignancy in this case.

Keyword

Stomach neoplasms; Adenocarcinoma; Acanthosis nigricans

MeSH Terms

Acanthosis Nigricans*
Adenocarcinoma*
Aged
Female
Gastrointestinal Tract
Humans
Hypertrophy
Lip
Membranes
Pigmentation
Stomach Neoplasms