Korean J Med.
2002 Oct;63(4):402-410.
The effect of renal calcium excretion on bone mineral metabolism of postmenopausal women in Korea
- Affiliations
-
- 1Department of Internal Medicine, Miz Medi Hospital, Seoul, Korea. okwendo@yahoo.co.kr
- 2Department of Family Medicine, Miz Medi Hospital, Seoul, Korea.
- 3Department of Gynecology, Miz Medi Hospital, Seoul, Korea.
- 4Department of Infertility Research Center, Miz Medi Hospital, Seoul, Korea.
- 5Department of Radiology, College of Medicine, Inha University, Incheon, Korea.
- 6Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Abstract
-
BACKGROUND: Although all postmenopausal women are estrogen deficient, women who have postmenopausal osteoporosis may have some defects, in addition to estrogen deficiency, that explain for their higher rates of bone resorption and greater bone loss, relative to those who do not. To test the hypothesis that one of the defects is an impairment in renal calcium conservation, we have investigated relationship between urinary calcium excretion and bone mineral metabolism of postmenopausal women in Korea.
METHODS
We have measured 24-hour urinary calcium level; serum osteocalcin level, serum alkaline phosphatase level; urine deoxypyridinoline level; and bone mineral density in 224 early postmenopausal, 158 late postmenopausal and 145 premenopausal women.
RESULTS
33.0 percent (74/224) of early postmenopausal women in Korea had urinary calcium excretion exceeding 4 mg/kg per day. The early postmenopausal women had higher (p < 0.05) values for mean urinary calcium to creatinine ratio of 0.241+/-0.008 mg/mg of creatinine vs. 0.209+/-0.010 mg/mg of creatinine and higher (p < 0.001) mean serum calcium level of 9.15+/-0.02 mg/dL vs. 8.92+/-0.03 mg/dL than the premenopausal women. Hypercalciuric group of early postmenopausal women had higher (p < 0.05) values for mean urine deoxypyridinoline level (8.6+/-0.4 nMol/mMol Vs. 7.7+/-0.2 nMol/mMol), higher (p < 0.05) mean serum alkaline phosphatase level (73.4+/-2.3 U/L Vs. 67.7+/-1.4 U/L) and lower (p < 0.05) mean bone mineral density of femur neck (0.785+/-0.012 g/cm2 Vs. 0.815+/-0.008 g/cm2) than the normocalciuric group.
CONCLUSION
The early postmenopausal women had larger numbers of hypercalciuric women and higher values for urinary calcium excretion than the premenopausal women. Hypercalciuric group of early postmenopausal women had higher values for biochemical markers of bone turnover and lower bone mineral density of femur neck than the normocalciuric group. We suggest that hypercalciuria could be accounted for the partial cause of postmenopausal osteoporosis, but further studies are needed to elucidate the direct effect about that.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The relationship between urinary sodium excretion and bone mineral metabolism of climacteric women in Korea
- Estrogen Replacement Therapy Continuously Combined with Progesterone; Effect on Bone Mineral Density and Lipid Metabolism
- A Comparative Study of Bone Mineral Density and Urinary Bone Metabolic Makers according to the Nutrients Intake Levels in Postmenopausal Women
- The effects of 1alpha-hydroxyvitamin D3 on the Bone Mineral Density and Bone Metabolism in Postmenopausal Women
- Effect of Soy Isoflavone Supplementation on Bone Metabolism Marker and Urinary Mineral Excretion in Postmenopausal Women
