Korean J Lab Med.  2005 Dec;25(6):421-424.

A Case of Disseminated Infection Due to Scedosporium apiospermum in a Liver-transplantation Recipient

• Chung JW
• Park SJ
• Sung H
• Kim MN
• Kim BS
• Lee SG

Abstract

Scedosporium apiospermum, an anamorph of Pseudallescheria boydii, is a ubiquitous saprophytic mold. Now a day, S. apiospermum is an emerging pathogen related to a significant morbidity and high mortality in transplant recipients. For the first time in Korea, we report a case of disseminated infection caused by S. apiospermum after liver transplantation. A 47-year-old woman underwent living donor liver transplantataion for billiary cirrhosis. She was treated with cyclosporine A, methylprednisolone, and prophylactic antibiotics including amphotericin B. She was found to have developed pneumonia and brain abscess at postoperative day 9 and 17 by chest X-ray and brain CT, respectively. Cultures of endotracheal aspirates and aspirates of brain abscess yielded S. apiospermum. Despite of antifungal therapy with amphotericin B, voriconazole, and caspofungin and removal of mycotic aneurysm of the brain, the patient died on postoperative day 33.

Keyword

Scedosporium apiospermum; Liver transplantation; Disseminated infection; Voriconazole

MeSH Terms

Amphotericin B
Aneurysm, Infected
Anti-Bacterial Agents
Brain
Brain Abscess
Cyclosporine
Female
Fibrosis
Fungi
Humans
Korea
Liver
Liver Transplantation
Living Donors
Methylprednisolone
Middle Aged
Mortality
Pneumonia
Pseudallescheria
Scedosporium*
Thorax
Transplantation
Amphotericin B
Anti-Bacterial Agents
Cyclosporine
Methylprednisolone