Korean J Hematol.
1998 Aug;33(2):284-288.
A Case of Rifampin-Induced Thrombocytopenia Associated with Specific Antibodies for Platelet Glycoprotein Ib/IX and IIb/IIIa
- Affiliations
-
- 1Department of Clinical Pathology, Pochon CHA University Medical College, Pundang CHA Hospital, Sungnam, Korea.
- 2Department of Internal Medicineand, Pochon CHA University Medical College, Pundang CHA Hospital, Sungnam, Korea.
- 3Department of Pediatrics, Pochon CHA University Medical College, Pundang CHA Hospital, Sungnam, Korea.
- 4Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- Rifampin is sometimes associated with hematologic complications such as hemolytic anemia or thrombocytopenia. Patients with drug-induced thrombocytopenia develop a drug- dependent antibody that binds to platelets in the presence of the drug causing platelet clearance. It has been previously proposed that the antibody binds the drug, resulting in an immune complex that is then adsorbed onto platelets. However, it has been recently known that drug-dependent antibodies bind to one or more of the platelet membrane glycoprotein Ib, IIb, IIIa, and IX. We, hereby, report a case of rifampin-induced thrombocytopenia in which drug-dependent antibody specific for platelet glycoprotein Ib/IX and IIb/IIIa was demonstrated by modified antigen capture ELISA method. The case was a 37 year-old female who had had pulmonary tuberculosis and taken antituberculous regimen including rifampin. Intermittent epistaxis appeared 10 days after treatment with rifampin. She was admitted to hospital due to gingival bleeding for 3 days and menorrhagia for 2 days. On admission, her platelet count was dropped to 7,000/microliter.
Keyword
MeSH Terms
-
Adult
Anemia, Hemolytic
Antibodies*
Antigen-Antibody Complex
Blood Platelets*
Enzyme-Linked Immunosorbent Assay
Epistaxis
Female
Glycoproteins*
Hemorrhage
Humans
Menorrhagia
Platelet Count
Platelet Glycoprotein GPIb-IX Complex
Rifampin
Thrombocytopenia*
Tuberculosis, Pulmonary
Antibodies
Antigen-Antibody Complex
Glycoproteins
Platelet Glycoprotein GPIb-IX Complex
Rifampin
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