Korean J Helicobacter Up Gastrointest Res.  2011 Jun;11(1):7-12. 10.7704/kjhugr.2011.11.1.7.

Helicobacter pylori Virulence Factors and Host Factors

• Kang BK
• Kim BW

• KMID: 2305183
• DOI: http://doi.org/10.7704/kjhugr.2011.11.1.7

Abstract

Helicobacter pylori (H. pylori) is one of the most common human infection world-wide. However, only a limited proportion of the infected population developed gastrointestinal diseases such as peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. These various outcomes of H. pylori infection may result from bacterial virulence factors, host factors such as genetic diversities, and environmental influences. Bacterial factors such as cagA PAI, vacA, adhesin and outer membrane proteins, and peptidoglycans are known to be associated with specific gastrointestinal diseases such gastric adenocarcinoma. Various cytokines including interleukin (IL)-1beta, IL-10, and tumor necrosis factor-alpha, and host immune reaction to the bacteria are closely related to specific diseases such as gastric adenocarcinoma and duodenal ulcer. In this article, we reviewed each factors and their relevance to the disease outcome.

Keyword

Helicobacter pylori; Virulence factors

MeSH Terms

Adenocarcinoma
Bacteria
Cytokines
Duodenal Ulcer
Gastrointestinal Diseases
Genetic Variation
Helicobacter
Helicobacter pylori
Humans
Interleukin-10
Interleukins
Lymphoma, B-Cell, Marginal Zone
Membrane Proteins
Peptic Ulcer
Peptidoglycan
Stomach Diseases
Tumor Necrosis Factor-alpha
Virulence Factors
Cytokines
Interleukin-10
Interleukins
Membrane Proteins
Peptidoglycan
Tumor Necrosis Factor-alpha
Virulence Factors