Korean J Gastrointest Motil.  2000 Nov;6(2):206-213.

The Effects of Ranitidine (300mg) and Omeprazole (10, 20mg) on Gastroesophageal Reflux and Intragastric pH in Healthy Subjects

• Kim YS
• Song CW
• Kim YH
• Kim HR
• Kim YB
• Hur BW
• Lee JW
• Jeen YT
• Kim CD
• Ryu HS
• Hyun JH

Abstract

BACKGROUND/AIMS: This study was done to compare the effects of Omeprazole (OMD) 10 or 20 mg with Ranitidine(RAN) 300 mg on intragastric acidity and gastroesophageal reflux in healthy subjects.
METHODS
Ten healthy male volunteers were studied after administrations of 5 days dosing with either RAN 300 mg, OMD 10 mg or 20 mg, once each morning. On the 5(th) day, intragastric pH and lower esophageal pH were measured by a dual channel antimony pH catheter for 10 hours.
RESULTS
Gastroesophageal reflux was reduced after administrations of RAN 300 mg, OMD 10 mg or 20 mg (p < 0.05) and there was no significant difference among the three drugs (p > 0.05). The gastric holding time of pH > 4 was significantly prolonged over fasting and postprandial periods after RAN 300 mg, OMD 10 mg or 20 mg administrations (p < 0.05). OMD 20 mg showed the most potent effect on gastric acid suppression (p < 0.05), but there was no significant difference between RAN 300 mg and OMD 10 mg (p > 0.05). OMD administrations (10 mg or 20 mg) exhibited a more potent effect on gastric acid suppression during the postprandial period than RAN 300 mg (p < 0.05).
CONCLUSIONS
OMD 10 mg was as potent as RAN 300 mg on inhibition of gastric acid, but less potent than OMD 20 mg. There was no difference among the three drugs in regard to gastroesophageal reflux in healthy subjects.

Keyword

Proton pump inhibitor; H2 receptor antagonist; Intragastric acidity; Gastroesophageal reflux

MeSH Terms

Antimony
Catheters
Fasting
Gastric Acid
Gastroesophageal Reflux*
Humans
Hydrogen-Ion Concentration*
Male
Omeprazole*
Postprandial Period
Ranitidine*
Volunteers
Antimony
Omeprazole
Ranitidine