Korean J Gastrointest Endosc.  2008 Sep;37(3):161-166.

Clinical Features of Re-infection of Helicobacter pylori after Successful Eradication

• Kim JH
• Yang HJ
• Jang ES
• Jo EJ
• Jo HJ
• Chun JY
• Choi JK
• Hwang SW
• Lee SH
• Park YS
• Hwang JH
• Kim JW
• Jung SH
• Kim NY
• Lee DH
• Jung HC
• Song IS

Abstract

BACKGROUND/AIMS
Studies on re-infection of Helicobacter pylori are limited. This study was designed to determine if there are clinical features of H. pylori re- infection related to gastroduodenal diseases or histological findings. METHODS: From a population of patients that were treated for H. pylori eradication from May 2003 to September 2007, 129 subjects were enrolled. Regimens were PPI-based triple or quadruple agents and follow-up methods were UBT, CLO or histology. RESULTS: A total of 29 subjects experienced a recurrence (within one year, 17 subjects; between one and two years, eight subjects; more than two years, four subjects). Recurrence periods were 2 to 32 months, and the mean period was 12.62+/-8.40 months. Among 29 subjects, eight subjects had chronic atrophic gastritis, 14 subjects had a peptic ulcer, five subjects had stomach cancer and two subjects had a MALT lymphoma; there were no statistical differences of the odds ratio between matched diseases. By use of the Updated Sydney System, neither H. pylori colonization density nor neutrophil infiltration nor monocyte infiltration grade in histology was associated with recurrence or re-infection. CONCLUSIONS: Neither histological findings nor gastroduodenal diseases was associated with H. pylori re-infection. The re-infection rate in this study was approximately 6.2%. This rate was slightly higher than rates reported in other recent studies in Korea.

Keyword

Helicobacter pylori; Recurrence; Reinfection; Gastroduodenal diseases; Histology

MeSH Terms

Colon
Follow-Up Studies
Gastritis, Atrophic
Helicobacter
Helicobacter pylori
Humans
Korea
Monocytes
Neutrophil Infiltration
Odds Ratio
Peptic Ulcer
Recurrence
Stomach Neoplasms