Korean J Dermatol.  2000 Apr;38(4):546-548.

Hand-Foot Syndrome with Nail Changes Induced by Fluorouracil

Affiliations
  • 1Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Many chemotherapeutic agents induce both local and systemic cutaneous toxicity. Among them, Fluorouracil (5-FU) induces various cutaneous reaction, including hand-foot syndrome, hypersensitivity, hyperpigmentation and nail changes. We describe a male patient with rectal cancer, who developed combined features of hand-foot syndrome and nail changes during chemotherapy with 5-FU.

Keyword

Hand-foot syndrome; Nail changes; Fluorouracil

MeSH Terms

Drug Therapy
Fluorouracil*
Hand-Foot Syndrome*
Humans
Hyperpigmentation
Hypersensitivity
Male
Rectal Neoplasms
Fluorouracil
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