Korean J Intern Med.  2007 Jun;22(2):109-112. 10.3904/kjim.2007.22.2.109.

Hand-Foot Syndrome with Scleroderma-like Change Induced by the Oral Capecitabine: A Case Report

• Lee SD
• Kim HJ
• Hwang SJ
• Kim YJ
• Nam SH
• Kim BS

• KMID: 1091871
• DOI: http://doi.org/10.3904/kjim.2007.22.2.109

Abstract

Hand-foot syndrome (HFS) is a well-known adverse event associated with capecitabine, a prodrug of 5-Fluorouracil (5-FU). HFS manifests as acral erythema, with swelling and dysesthesia of the palms and plantar aspects of the feet, which in the absence of dosage reduction or drug cessation, progresses to moist desquamation and ulceration, resulting in serious infections and loss of function. We report a case of HFS, with scleroderma-like changes, apparently induced by capecitabine. In our case, capecitabine, given in the recommended dosage was observed to lead to hyperpigmentation of the palms and soles, followed by a distinct keratoderma-like thickening unfamiliar to usual cases of HFS. This case may provide important clues for revising the definition of HFS, and allow the formation of effective preventive strategies for this side effect of chemotherapy.

Keyword

Hand-foot syndrome; Capecitabine; Scleroderma

MeSH Terms

Administration, Oral
Aged
Antimetabolites, Antineoplastic/administration & dosage/*adverse effects
Deoxycytidine/administration & dosage/adverse effects/*analogs & derivatives
Fluorouracil/administration & dosage/adverse effects/*analogs & derivatives
Foot Dermatoses/*chemically induced/diagnosis
Hand Dermatoses/*chemically induced/diagnosis
Humans
Male
Risk Factors
Scleroderma, Localized/*chemically induced/diagnosis