Korean J Dermatol.
2004 Mar;42(3):370-372.
A Case of Nicolau Syndrome Due to Diclofenac Sodium
- Affiliations
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- 1Department of Dermatology, Wonkwang University School of Medicine, Iksan, Korea. sdpark@wonkwang.ac.kr
- 2Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
Abstract
- Nicolau syndrome is defined as local cutaneous and sometimes muscular necrosis observed at the injection site of intramuscular preparations. It is characterized by severe pain immediately after the injection and variable degrees of skin necrosis. The only treatment is conservative. A 46-year-old man presented with painful skin necrosis on his buttock after the injection of diclofenac sodium. Histopathologic examination showed necrosis of the epidermis and upper 2/3 of the dermis. The lesion was treated conservatively with topical antibiotic ointment. We report a rare case of Nicolau syndrome due to diclofenac sodium.
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