Korean J Dermatol.
2006 Dec;44(12):1464-1466.
A Case of Nicolau Syndrome Treated by Surgical Excision
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- 1Department of Dermatology, College of Medicine, Dong-A University, Busan, Korea. khkim@dau.ac.kr
Abstract
- Nicolau syndrome or embolia cutis medicamentosa is an acute necrotic condition of skin that follows intramuscular injection of drugs. A 36-year-old man developed a painful, purpuric and erythematous patch on his left buttock following an intramuscular injection of diclofenac sodium. Histologically, the patch lesion displayed epidermal necrosis, dermal degeneration, and vascular thrombosis. We report a rare case of Nicolau syndrome following intramuscular injection of diclofenac sodium. In our case, the patient was successfully treated by surgical excision with primary closure.
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