Korean J Dermatol.
2007 Jun;45(6):577-580.
A Case of Localized Scleroderma-like Lesion Following Extravasation of Oxaliplatin
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- 1Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. yymmpark@hotmail.com
Abstract
- While extravasation from intravenous lines is common and usually benign, leakage of certain cytotoxic drugs can cause severe tissue injury varying from irritation to necrosis. The severity of tissue injury is dependent on the type and concentration of the chemotherapeutic agent and the quantity injected. Oxaliplatin is a novel class of platinum chemotherapeutic agent used in refractory adenocarcinoma. With increased use of oxaliplatin as a potent anticancer drug, there has been increasing numbers of irreversible local tissue reactions at venous administration sites. This report describes a case of the rapid onset of scleroderma-like lesion following a single episode of oxaliplatin extravasation from an implanted chemo-port in a 72-year-old patient with metastatic gastric cancer.
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