Korean J Dermatol.  2009 Oct;47(10):1196-1198.

Isotretinoin Treatment for the Recalcitrant Acne on a Patient with Apert Syndrome

Affiliations
  • 1Department of Dermatology, College of Medicine, Inha University, Incheon, Korea. garden@inha.ac.kr

Abstract

Apert syndrome is a rare genetic craniofacial disorder associated with premature fusion of multiple cranial sutures and syndactyly. It is caused by mutation in the fibroblast growth factor receptor 2 genes. The clinical findings are characterized by the typical dysmorphic facial features, including hypertelorism, proptosis and cleft palate. Most of these patients have widespread, severe acne involving the face, chest, back and forearms during puberty and the acne is unresponsive to conventional treatments. We report here on a patient with the recalcitrant acne of Apert syndrome and the patient had failed to respond to conventional acne treatment, but the acne was successfully treated with isotretinoin

Keyword

Acne; Apert syndrome; Isotretinoin

MeSH Terms

Acne Vulgaris
Acrocephalosyndactylia
Cleft Palate
Cranial Sutures
Exophthalmos
Forearm
Humans
Hypertelorism
Isotretinoin
Puberty
Receptor, Fibroblast Growth Factor, Type 2
Syndactyly
Thorax
Isotretinoin
Receptor, Fibroblast Growth Factor, Type 2
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