Korean J Dermatol.  2019 Nov;57(9):548-550.

Severe Hyperhidrosis in Apert Syndrome: A Case Report

• Lee H
• Choi S
• Yang JH
• Moon J
• Suh DH

Abstract

Apert syndrome is a rare genetic disorder characterized by malformations of the skull, face, hands, and feet. We report a case of severe hyperhidrosis in a 13-month-old female infant with Apert syndrome who was born with craniosynostosis, midface hypoplasia, and syndactyly of both hands. She had a history of excessive sweating since birth and this was confirmed using the iodine-starch test. Hyperhidrosis was first reported as a key cutaneous manifestation of Apert syndrome in 1993. However, the main focus in the field of dermatology is on antibiotic-refractory acne, which serves as another cutaneous hallmark of the disease. This is the first report in the Korean literature that describes hyperhidrosis in Apert syndrome. We highlight the presentation of hyperhidrosis as a key cutaneous manifestation in Apert syndrome.

Keyword

Apert syndrome; Hyperhidrosis

MeSH Terms

Acne Vulgaris
Acrocephalosyndactylia*
Craniosynostoses
Dermatology
Female
Foot
Hand
Humans
Hyperhidrosis*
Infant
Parturition
Skull
Sweat
Sweating
Syndactyly