Korean J Anesthesiol.  2004 Oct;47(4):527-531. 10.4097/kjae.2004.47.4.527.

Effects of Preemptive Gabapentin on Postoperative Pain after Mastectomy

• Kim SI
• Park DY
• Ok SY
• Kim SC

• KMID: 2299289
• DOI: http://doi.org/10.4097/kjae.2004.47.4.527

Abstract

BACKGROUND: The aim of the present study was to investigate the effect of preemptive gabapentin on postoperative pain and opioid consumption in patients undergoing mastectomy.
METHODS
In a randomized, double-blind study, 41 patients received a single dose of oral gabapentin 900 mg with routine premedicantion (GABA group, n = 21) or only routine premedication without gabapentin (control group, n = 20) 1 h before surgery. Patients received intravenous patient-controlled analgesia using fentanyl for postoperative analgesia. VAS scores for pain at rest and during movement, sedation scores, side effects, and fentanyl consumptions were assessed at 6 and 24 h after surgery.
RESULTS
No significant differences were found between the two groups in terms of pain scores, side effects, or fentanyl consumptions for 24 h postoperatively. However, patients in the GABA group were more sedated at 6 h postoperatively than patients in the control group (P < 0.05).
CONCLUSIONS
The preemptive administration of oral gabapentin at 900 mg did not reduce postoperative pain or fentanyl consumption after mastectomy during the 24 h period following surgery.

Keyword

gabapentin; postoperative pain

MeSH Terms

Analgesia
Analgesia, Patient-Controlled
Double-Blind Method
Fentanyl
gamma-Aminobutyric Acid
Humans
Mastectomy*
Pain, Postoperative*
Premedication
Fentanyl
gamma-Aminobutyric Acid