Korean J Anesthesiol.  2001 Mar;40(3):389-396. 10.4097/kjae.2001.40.3.389.

The Effect of Preemptive Local Infiltration of Lidocaine and Gabapentin on Postoperative Pain in Rats

• Kim HK
• Lee HS
• Kim IS
• Baik SW
• Kwon JY
• Shin SU

• KMID: 2236810
• DOI: http://doi.org/10.4097/kjae.2001.40.3.389

Abstract

BACKGROUND: Preemptive analgesia may improve postoperative antinociceptive treatment that prevents the development of central sensitization which contributes to post-injury pain hypersensitivity. However, beneficial effects of preemptive analgesia appear controversial. The purpose of this study was to examine the effect of pre- and post-incisional local infiltration of lidocaine and gabapentin on incisional pain in rats.
METHODS
Thirty five male rats were divided into 7 groups; control group (n = 5), pre-lidocaine infiltration group (n = 5), post-lidocaine infiltration group (n = 5), pre-gabapentin 10 mg infiltration group (n = 5), post-gabapentin 10 mg infiltration group (n = 5), pre-gabapentin 30 mg infiltration group (n = 5), and post-gabapentin 30 mg infiltration group (n = 5). To evaluate postoperative mechanical hyperalgesia in injured feet, withdrawal thresholds were measured by calibrated von Frey filaments at 2 hrs, 1, 2, 3, 4, and 5 days after an incision.
RESULTS
The pre-lidocaine infiltration group shows better analgesic effects than post-lidocaine infiltration group until postoperative day 1 (P < 0.05). The gabapentin infiltration groups were effective in postoperative pain management but there were no significant differences between pre- and post- incisional treatment.
CONCLUSIONS
A preemptive lidocaine injection has a good analgesic effect on incisional pain. Gabapentin also has a good analgesic effect on incisional pain.

Keyword

Analgesia: preemptive; Anesthetics, local: lidocaine; Animals: rats; Anticonvulsants: gabapentin

MeSH Terms

Analgesia
Animals
Central Nervous System Sensitization
Foot
Humans
Hyperalgesia
Hypersensitivity
Lidocaine*
Male
Pain, Postoperative*
Rats*
Lidocaine