Korean J Anesthesiol.  2001 Jul;41(1):39-46. 10.4097/kjae.2001.41.1.39.

Effect of Epidural Ketamine Combined with Bupivacaine and Meperidine on Postoperative Pain and Analgesic Consumption after Cesarean Section

• Lee HJ
• Sung CH

• KMID: 2298988
• DOI: http://doi.org/10.4097/kjae.2001.41.1.39

Abstract

BACKGROUND: Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with analgesic properties. This study was undertaken to evaluate the potential utility of epidural ketamine combined with meperidine and bupivacaine for postoperative patient-controlled epidural analgesia (PCEA) after cesarean section.
METHODS
Forty-five patients received epidural catheterization in the L3-4 intervetebral space and underwent cesarean section under epidural anesthesia. In the recovery room, these patients were randomly allocated to 3 groups; group I (control; n = 15) received 1 mg/ml bupivacaine and 1 mg/ml meperidine, group II (n = 15) received 1 mg/ml bupivacaine and 1 mg/ml meperidine with 0.25 mg/ml ketamine, group III (n = 14) received 1 mg/ml bupivacaine and 1 mg/ml meperidine with 0.75 mg/ml ketamine using a PCEA device for postoperative pain control. The analgesic effects and PCEA consumption were assessed at 6, and 24 hours after surgery. Side effects were also evaluated.
RESULTS
There were no statistically significant differences in the visual analogue scale for pain, the consumption of the analgesics and side effects among the groups.
CONCLUSIONS
Epidural ketamine combined with bupivacaine and meperidine did not improve postoperative analgesia, nor did it reduce consumption of the analgesics and side effects.

Keyword

Analgesia: epidural; patient-controlled; Analgesics: bupivacaine; ketamine; meperidine; Pain: postoperative

MeSH Terms

Analgesia
Analgesia, Epidural
Analgesics
Anesthesia, Epidural
Bupivacaine*
Catheterization
Catheters
Cesarean Section*
Female
Humans
Ketamine*
Meperidine*
N-Methylaspartate
Pain, Postoperative*
Pregnancy
Recovery Room
Analgesics
Bupivacaine
Ketamine
Meperidine
N-Methylaspartate