J Korean Acad Fam Med.  2005 Apr;26(4):218-223.

The Relationship between Serum DHEA-s Level and TAS in Healthy Adults

• Lee HR
• Chung DH
• Im JA
• Kim KC
• Lee HR
• Lee DC

Abstract

BACKGROUND: DHEA is the most abundant steroid hormone secreted from the adrenal cortex and has several roles such as increasing insulin sensitivity, lowering serum lipid, improving obesity, and anti-cancer effects. DHEA levels vary profoundly and levels decline as age increases. But the role of DHEA in the aging process is not yet fully understood. TAS which provides information of one's antioxidant capacity, also decreases with age. In this study, we investigated the relationship between TAS and serum DHEA-s concentration.
METHODS
By reviewing the medical records of 197 healthy adults, we determined the serum levels of DHEA-s and TAS according to BMI, pulse pressure, WBC, hs-CRP, A/G ratio, LDL-cholesterol, triglyceride, ferritin, uric acid and total bilirubin. We studied the relationship between the parameters by Pearson correlation coefficients and multiple regression analysis.
RESULTS
The mean level for TAS and serum DHEA-s was 1.20 mml/L and 177.3 ug/mL, respectively. Serum DHEA-s correlated positively with TAS (r=0.44) and negatively for age (r=-0.44). WBC triglyceride and uric acid also showed statistically significant correlations. But, according to multiple regression analysis DHEA-s only correlated with TAS and age.
CONCLUSION
Serum DHEA-s correlates positively with TAS.

Keyword

DHEA-s; TAS; age

MeSH Terms

Adrenal Cortex
Adult*
Aging
Bilirubin
Blood Pressure
Dehydroepiandrosterone
Ferritins
Humans
Insulin Resistance
Medical Records
Obesity
Triglycerides
Uric Acid
Bilirubin
Dehydroepiandrosterone
Ferritins
Uric Acid