Korean J Urol.  2002 Jan;43(1):1-6.

The Expression of Caspase 3 and p21 in Renal Cell Carcinoma

Affiliations
  • 1Department of Urology, Korea University College of Medicine, Seoul, Korea.
  • 2Department of Pathology, Korea University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
The objective of this study was to evaluate the Caspase 3 and p21 expression level and to understand the correlation between Caspase 3 expression and the clinical factors in renal cell carcinoma.
MATERIALS AND METHODS
Forty-two patients with renal cell carcinoma were enrolled in this study. Immunohistochemical staining of Caspase 3 and p21 was performed in formalin-fixed and paraffin-embedded tissue sections using rabbit polyclonal antibody (Caspase 3) and mouse antibody (p21). The Caspase 3 and p21 expression levels were compared with the TNM stage, Fuhrman grade, pathological type and survival rates.
RESULTS
The Caspase 3 expression level correlated only with the Fuhrman grade (p=0.017). There was no significant correlation between the Caspase 3 and p21 expression level. The prognostic values did not correlate with the Caspase 3 and p21 expression level.
CONCLUSIONS
The prognostic value of the Caspase 3 expression level in renal cell carcinoma was insufficient. The relationship between Caspase 3 and p21 was not proven in renal cell carcinoma, and new factors may be implicated with Caspase 3.

Keyword

Caspase 3; Renal cell carcinoma; Prognosis; Apoptosis

MeSH Terms

Animals
Apoptosis
Carcinoma, Renal Cell*
Caspase 3*
Humans
Mice
Prognosis
Survival Rate
Caspase 3
Full Text Links
  • KJU
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr