Korean J Urol.
2002 Jan;43(1):1-6.
The Expression of Caspase 3 and p21 in Renal Cell Carcinoma
- Affiliations
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- 1Department of Urology, Korea University College of Medicine, Seoul, Korea.
- 2Department of Pathology, Korea University College of Medicine, Seoul, Korea.
Abstract
- PURPOSE
The objective of this study was to evaluate the Caspase 3 and p21 expression level and to understand the correlation between Caspase 3 expression and the clinical factors in renal cell carcinoma.
MATERIALS AND METHODS
Forty-two patients with renal cell carcinoma were enrolled in this study. Immunohistochemical staining of Caspase 3 and p21 was performed in formalin-fixed and paraffin-embedded tissue sections using rabbit polyclonal antibody (Caspase 3) and mouse antibody (p21). The Caspase 3 and p21 expression levels were compared with the TNM stage, Fuhrman grade, pathological type and survival rates.
RESULTS
The Caspase 3 expression level correlated only with the Fuhrman grade (p=0.017). There was no significant correlation between the Caspase 3 and p21 expression level. The prognostic values did not correlate with the Caspase 3 and p21 expression level.
CONCLUSIONS
The prognostic value of the Caspase 3 expression level in renal cell carcinoma was insufficient. The relationship between Caspase 3 and p21 was not proven in renal cell carcinoma, and new factors may be implicated with Caspase 3.
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