J Korean Acad Child Adolesc Psychiatry.
2007 Oct;18(2):109-116.
The Korean Practice Parameter for the Treatment of Pervasive Developmental Disorders: Pharmacological Treatment
- Affiliations
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- 1Department of Psychiatry, Gachon University of Medicine and Science, Incheon, Korea.
- 2Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- 3Department of Neuropsychiatry, Chungbuk National University College of Medicine, Cheongju, Korea.
- 4Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- 5Department of Neuropsychiatry, Eulji University College of Medicine, Daejeon, Korea.
- 6Department of Neuropsychiatry, Kyungpook National University College of Medicine, Daegu, Korea.
- 7Department of Neuropsychiatry, Hanyang University Medical School, Seoul, Korea.
- 8Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju, Korea. jsahn@yonsei.ac.kr.
Abstract
- The objective of this review is to establish practice parameters for pharmacological treatment of children and adolescents with pervasive developmental disorders. We performed a detailed review of the literature, including a wide range of controlled clinical trials, open trials, case reports, and side-effect profiles of related drugs. Few medications have a treatment indication for pervasive developmental disorders, and few studies with well-controlled methodology are available for evaluating treatment results. Pharmacological treatments focus on associated target symptoms because symptom reduction may improve educational and social ability and enhance quality of life. Well-controlled trials have been conducted for some SSRI(selective serotonin reuptake inhibitor) antidepressants, risperidone, and methylphenidate, and showed reduction of some target symptoms. Since the medications are not specific to autism and do not treat core symptoms of the disorder, their potential side effects should be carefully considered. Family education is necessary to give proper information on target symptoms, limitation of drug treatments, and risks.
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