Effectiveness of Magnesium Oxide and Sodium Thiosulfate in Calcium Oxalate Crystallization

Moon, Young Tae; Bang, Chang Ho; Kim, Tae Hyoung; Ahn, Seung Yong; Kim, Mi Kyung

Abstract

We investigated the comparative effect of magnesium and thiosulfate on the calcium oxalate crystallization. Magnesium is a strong inhibitor of calcium oxalate crystallization and it is sported to inhibit calcium phophate by about 20%. Even if it's mechanism is not clearly known, thiosulfat can resolve 250~100,000 times more than other calcium salts when it is combined with calcium. Wistar rats were fed by 1.0% ethylene glycol (EG) mixed with water. 500mg of magnesium oxide (MgO) per 100gm chows and 10mMo1 of S2O3 per 100gm chows were provided by oral intake respectively. Forty eight wistar rats were divided into following 6 groups. Each group has equal 8 wistar rats; A group (normal chow and water), B group (normal chow and 1%EG), C group (MgO and 1%EG), D group (MgO and water), E group (S2O3 and 1%EG), and F group (S2O3 and water). First, we examined calcium oxalate crystallization on bladder aspiration urine for 6 groups before the experiment and every week for 4 weeks after the experiment. Second, we also examined the degree of formation of calcium oxalate crystallization in renal tissue under polarizing microscope. Calcium oxalate crystallization was found in all 8 wistar rats in B group while it was not round in A, D, F group. Calcium oxalate crystallization was also found in one out of 8 wistar rats in C group, and 5 out of 8 wistar rats in E group. In conclusion, we believe that both MgO and sodium thiosulfate are effective in preventing calcium oxalate stone, and we also believe MgO is more elective than sodium thiosulfate. We think that further researches on administrating methods, the side effects and dosage of these two agents in human are necessary.