Korean J Urol.  1995 Jul;36(7):731-735.

Management of Urinary Stone with Potassium Citrate

Affiliations
  • 1Department of Urology, Kyungpook National University, School of Medicine, Taegu, Korea.

Abstract

Potassium citrate therapy caused a sustained increase in urinary pH and potassium, and restored urinary citrate to normal levels. No significant changes occurred in urinary uric acid, oxalate, sodium or phosphorus levels. Owing to these physiological changes, uric acid solubility increased, urinary saturation of calcium oxalate decreased and the propensity for spontaneous nucleation of calcium oxalate was reduced to normal. Therefore, the Physicochemical environment of urine following treatment become less conductive to the crystallization of calcium oxalate or uric acid. Twenty six patients with uric acid nephrolithiasis with or without calcium nephrolithiasis underwent treatment and long-term preventive management (mean of 20.8 months) with potassium citrate. Urinary pH increased from acid (5.0-5.5) to normal (6.5-7.0) during treatment. During the period of preventive management, stones were not developed.

Keyword

Urinary stone; Management; Potassium citrate

MeSH Terms

Calcium
Calcium Oxalate
Citric Acid
Crystallization
Humans
Hydrogen-Ion Concentration
Nephrolithiasis
Oxalic Acid
Phosphorus
Potassium Citrate*
Potassium*
Solubility
Uric Acid
Urinary Calculi*
Calcium
Calcium Oxalate
Citric Acid
Oxalic Acid
Phosphorus
Potassium
Potassium Citrate
Uric Acid
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