J Clin Neurol.  2012 Dec;8(4):301-304. 10.3988/jcn.2012.8.4.301.

Association between the G252A Tumor Necrosis Factor-beta Gene Polymorphism and Medication-Overuse Headache

Affiliations
  • 1Department of Pathophysiology, Showa University School of Pharmacy, Tokyo, Japan. masakazu@pharm.showa-u.ac.jp
  • 2Department of Neurology, Showa University School of Medicine, Tokyo, Japan.
  • 3Center of Pharmaceutical Education, Showa University School of Pharmacy, Tokyo, Japan.

Abstract

BACKGROUND
AND PURPOSE: Migraine patients are particularly prone to the complication of medication-overuse headache (MOH). Although it has been shown that A allele carriers for the tumor necrosis factor (TNF)-beta gene G252A polymorphism are at high risk of the development of migraine without aura, the relationship between the TNF-beta gene G252A polymorphism and MOH is unknown. We investigated whether the TNF-beta gene G252A polymorphism is involved in the aggravation of migraine by overuse of medications.
METHODS
Forty-seven migraine patients (6 males and 41 females; age 36.4+/-10.3 years, mean+/-SD) and 22 MOH patients (1 male and 21 females; age 39.6+/-9.9 years) who had migraine were included in this study. The genotype for the TNF-beta gene G252A polymorphism was determined by polymerase-chain-reaction restriction-fragment-length polymorphism analysis.
RESULTS
The distribution of TNF-beta gene G252A genotype frequency differed significantly between migraine and MOH patients (p=0.013). The G/G genotype was carried by 23% of the migraine patients but it was absent in MOH patients.
CONCLUSIONS
G/G genotype carriers appear to be less susceptible to the aggravation of migraine by overuse of medications. The G252A TNF-beta gene polymorphism may be one of the factors contributing to the complications of MOH in patients with migraine.

Keyword

medication overuse headache; migraine; tumor necrosis factor gene
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