Korean J Psychopharmacol.  2011 Jul;22(3):161-165.

A Case of Transient Psychosis after Sustained Release Bupropion Overdose

• Na KS
• Lee SI
• Jung HY

Abstract

Bupropion is a unique antidepressant with enhancing both noradrenergic and dopaminergic neurotransmission without altering serotonergic system. Given its pharmacodynamics and structural similarity to amphetamine, the possibility of bupropionrelated psychosis has been reported. The authors describe a 22-year-old woman who presented psychotic symptoms after taking 10 tablets of sustained release bupropion (bupropion SR) 150 mg (total 1,500 mg) and lorazepam 0.5 mg (total 5 mg). Visual hallucinations developed at 17 hours after overdose, while paranoid ideation and aggressive behaviors developed at 24 hours after overdose. The psychotic symptoms remitted on the fifth day of antipsychotics treatment. She remained psychiatrically stable without any clinically significant symptoms during 3-month follow-up. This case raises issue about the possible relationship between bupropion overdose and transient psychosis.

Keyword

Bupropion; Antidepressant; Psychosis; Overdose

MeSH Terms

Amphetamine
Antipsychotic Agents
Bupropion
Female
Follow-Up Studies
Hallucinations
Humans
Lorazepam
Morphinans
Psychotic Disorders
Synaptic Transmission
Tablets
Young Adult
Amphetamine
Antipsychotic Agents
Bupropion
Lorazepam
Morphinans
Tablets