Korean J Psychopharmacol.  2011 Jul;22(3):154-156.

Two Cases of Reversible Skin Rash Associated with Quetiapine-Valproate Combination Treatment

Affiliations
  • 1Department of Psychiatry, Seoul National Hospital, Seoul, Korea. drshe@hanmail.net

Abstract

Skin rash is one of the most common drug-induced side effects. Most of the lesions are usually self-limited and subsided by quitting causal drugs. However, generally, prescriptions involve intake of various drugs, so it is not easy to establish the cause. We report two cases of the patients who had experienced the skin rash in their first manic episode of bipolar I disorder while taking valproate and quetiapine. Their lesions had clearly subsided after quetiapine and valproate were stopped. In clinical practice, polypharmacy is an effective treatment strategy of bipolar disorder. Thus in case of prescribing various drugs, the close observation of drug-induced side effects is needed and drug interaction should be kept in mind.

Keyword

WordszzDrug eruptions; Quetiapine; Valproic acid

MeSH Terms

Bipolar Disorder
Dibenzothiazepines
Drug Interactions
Exanthema
Humans
Polypharmacy
Prescriptions
Skin
Valproic Acid
Quetiapine Fumarate
Dibenzothiazepines
Valproic Acid
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