Korean J Psychopharmacol.  2006 Jan;17(1):60-69.

Association Studies of the CT Repeat Polymorphism in the Cholecystokinin B Receptor Gene with the Diagnosis and the Response of Pharmacotherapy in Korean Patients with Panic Disorder

• Choi YH
• Woo JM
• Bae JH
• Cho DY
• Kim W

Abstract

OBJECTIVE
This study aimed to test the possible association between Cholecystokinin B receptor (CCKBR) promoter gene and panic disorder.
METHODS
262 patients with panic disorder and 76 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-based method.
RESULTS
Allele distribution of CT repeat polymorphism in patients with panic disorder was not different from those of the controls. However, after excluding the patients with panic disorder comorbid with major depressive disorder and other anxiety disorder, we found out the significant association of CCKBR (CT)n repeat with the panic disorder without comorbidities. And we analysed the data as a di-allelic polymorphism with a short (140-162 bp) and a long (164-180 bp) allele. In the di-allelic analysis, there was an excess of the shorter allele in patients with panic disorder.
CONCLUSION
The present study suggested that the CCKBR promoter dinucleotide polymorphism may have a potential role for susceptibility to panic disorder in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

Keyword

Panic disorder; Cholecystokinin B receptor; Polymorphism; Korean

MeSH Terms

Alleles
Anxiety Disorders
Cholecystokinin*
Comorbidity
Depressive Disorder, Major
Diagnosis*
Drug Therapy*
Humans
Panic Disorder*
Panic*
Receptor, Cholecystokinin B*
Cholecystokinin
Receptor, Cholecystokinin B