Korean J Psychopharmacol.  2007 Jul;18(4):251-255.

Ziprasidone Induced Neutropenia

• Yang JC
• Kim SY
• Park TW
• Chung YC
• Chung SK
• Hwang IK

Abstract

Neutropenia and agranulocytosis are dangerous conditions seldom caused by antipsychotics. We report the case of a 35-year-old female patient who presented with neutropenia following ziprasidone administration. Ziprasidone was gradually increased to 160 mg/day in combination with escitalopram 10 mg/day. Following ziprasidone administration, her neutrophil count fell to 1700x10(3)/mm3, on day 45 and to 1500x10(3)/mm3 on day 57. Ziprasidone was immediately stopped, and quetiapine 25 mg was given from the next day onward, along with the escitalopram. Her neutrophil count rose to 2700x10(3)/mm3 2 days later, and was maintained at 2,900x10(3)/mm3 at 17 days after changing medication. To the best of our knowledge, this case represents the first report of ziprasidone - induced neutropenia in Korea. Further study is necessary to determine the incidence of neutropenia and its relationship with agranulocytosis secondary to ziprasidone.

Keyword

Neutropenia; Agranulocytosis; Ziprasidone; Antipsychotics

MeSH Terms

Adult
Agranulocytosis
Antipsychotic Agents
Citalopram
Female
Humans
Incidence
Korea
Neutropenia*
Neutrophils
Quetiapine Fumarate
Antipsychotic Agents
Citalopram