J Korean Rheum Assoc.  2002 Jun;9(2):137-140.

Deep Neck Infection due to Severe Neutropenia induced by Terbinafine in a Patient with Systemic Lupus Erythematosus

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Korea. ionos@kornet.net

Abstract

Terbinafine, a fungicidal agent used for the treatment of onychomycosis, has been found to be safe and adverse effects are usually mild and transient. Neutropenia is a rare side effect of terbinafine. Terbinafine-induced neutropenia have been reported 7 cases worldwide and these patients had no predisposing factors that give rise to developing neutropenia. To date there has not been reported in Korea. We report a case of systemic lupus erythematosus of 47-yearold female patient who developed deep neck infection requiring intravenous antibiotics, tracheostomy, granulocyte colony-stimulating factor(G-CSF) to recover from terbinafine-induced neutropenia.

Keyword

Terbinafine; Neutropenia; Systemic Lupus Erythematosus

MeSH Terms

Anti-Bacterial Agents
Causality
Female
Granulocytes
Humans
Korea
Lupus Erythematosus, Systemic*
Neck*
Neutropenia*
Onychomycosis
Tracheostomy
Anti-Bacterial Agents
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