Korean J Dermatol.  2006 Feb;44(2):201-205.

Two Cases of Anti-Ro and La Antibody-positive Cutaneous Lupus Erythematosus Probably Caused by Terbinafine

• Kim JW
• Kang HW

Abstract

Terbinafine is a drug for dermatophytosis, which is considered to be safe. However, susceptible patients are predisposed to drug-induced or exacerbated cutaneous lupus erythematosus (CLE). Herein, we describe two patients who had a new onset of CLE, mimicking an annular type of subacute cutaneous lupus erythematosus (SCLE), while taking terbinafine for presumed onychomycosis. Two female patients presented with erythematous annular eruptions after 4 to 6 weeks of oral terbinafine. Anti-Ro/La and anti-histone antibodies were positive. Their conditions improved after withdrawal of terbinafine. To the best of our knowledge, this is the first report to describe its association with anti-Ro/La-positive CLE in Korea, although there have been a few reports of terbinafine-induced CLE or SCLE in Western countries.

Keyword

Terbinafine; Ro; La; Cutaneous lupus erythematosus

MeSH Terms

Antibodies
Female
Humans
Korea
Lupus Erythematosus, Cutaneous*
Onychomycosis
Tinea
Antibodies