Korean J Dermatol.  1999 Nov;37(11):1649-1654.

Neonatal Lupus Erythematosus

Affiliations
  • 1Department of Dermatology, College of Medicine, Hallym University Chunchon, Korea.

Abstract

Neonatal lupus erythematosus (NLE) is a transplacentally acquired autoimmune disorder, which is characterized by cutaneous lesions and/or congenital heart block and less commonly hepatic and hematologic abnormalities. Affected infants acquire anti-SSA/Ro antibody, anti-SSB/La antibody or less commonly anti-U1RNP antibody transplacentally from maternal circulation and it is generally thought that these antibodies are pathogenic. We report a case of NLE in a 40-day-old neonate who had erythematous annular patches on his face and extremities. Serological studies were reactive for antinuclear antibody of the speckled pattern and positive for anti-SSA/Ro antibodies and anti-SSB/La antibodies in both mother and infant. Addition to these findings, his mother had complained photosensitivity and arthralgia and showed hematological abnormalities including anemia and leukopenia, so we diagnosed his mother as systemic lupus erythematosus.

Keyword

Neonatal lupus erythematosus; Anti-SSA/Ro antibody

MeSH Terms

Anemia
Antibodies
Antibodies, Antinuclear
Arthralgia
Extremities
Heart Block
Humans
Infant
Infant, Newborn
Leukopenia
Lupus Erythematosus, Systemic
Mothers
Antibodies
Antibodies, Antinuclear
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