Korean J Psychopharmacol.  2000 Dec;11(4):343-349.

Prolactin Response to the Administration of Risperidone and haloperidol in Patients with Schizophrenia and Other Psychotic Disorder

• Chung YC
• Park KH
• Kim DJ
• Park KY

Abstract

The purposes of this study were to compare the difference of prolactin responses to risperidone and haloperidol, the sex difference in prolactin responses to each drug and the difference of prolactin responses to both drug in each sex.
METHODS
The patients with schizophrenia, schizophreniform disorder, schizoaffective disorder, delusional disorder, brief psychotic disorder diagnosed by the criteria of DSM-IV were randomly assigned to risperidone group (n=18) or haloperidol group (n=15). Prolactin levels were measured before drug administration and at week 1, 2, 3, 4, 6 after drug administration by immunoradiometric assay.
RESULTS
Prolactin levels after risperidone administration were significantly (p<0.05) higher than those after haloperidol. There was no sex difference in the prolactin responses to haloperidol administration. As for risperidone administration, female showed significantly (p<0.05) higher prolcatin levels than male. There was no difference of prolactin responses to both drugs in male, but in female, prolactin levels after risperidone administration were significantly (p<0.05) higher than those after haloperidol.
CONCLUSION
Compared to haloperidol, risperidone can cause significantly higher prolactin response in female than male. Therefore one should consider whether there is a sexual side effects related to the elevated prolactin level especially in female during risperidone administration.

Keyword

Risperidone; Haloperidol; Prolactin

MeSH Terms

Diagnostic and Statistical Manual of Mental Disorders
Female
Haloperidol*
Humans
Immunoradiometric Assay
Male
Prolactin*
Psychotic Disorders*
Risperidone*
Schizophrenia*
Schizophrenia, Paranoid
Sex Characteristics
Haloperidol
Prolactin
Risperidone