J Breast Cancer.  2008 Dec;11(4):213-217. 10.4048/jbc.2008.11.4.213.

Malignant Fibrous Histiocytoma in the Breast: A Case Report

• Park JK
• Choi SH
• Kim SK
• Yun SS
• Baek JM
• Suh YJ
• Park WC
• Song BJ
• Oh SJ
• Kim JS
• Lee S
• Jung SS
• Min KO
• Kim HS

• KMID: 2286588
• DOI: http://doi.org/10.4048/jbc.2008.11.4.213

Abstract

Malignant fibrous histiocytoma is the most common form of soft tissue sarcoma during middle and late adulthood in the deep connective tissues of the extremities, abdominal cavity, and retroperitoneum. Primary breast sarcoma is a rare disease entity, comprising less than 1% of all breast malignancies. Malignant fibrous histiocytoma of the breast is very rare. We presented one case of a malignant fibrous histiocytoma of the right breast in a 49-year-old woman and report the case with a review of the literature.

Keyword

Breast; Fibrous histiocytoma; Malignant; Sarcoma

MeSH Terms

Abdominal Cavity
Breast
Connective Tissue
Extremities
Female
Histiocytoma, Benign Fibrous
Histiocytoma, Malignant Fibrous
Humans
Middle Aged
Rare Diseases
Sarcoma

Figure

• 

  Fig 1 The ultrasonographic findings of malignant fibrous histiocytoma. Several large hypoechoic & isoechoic masses are noted in lower half of right breast and part of them are located in subcutaneous layer (A) and lymph nodes in right axilla are enlarged (B). These findings are included in BI-RADS category 5.

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  Fig 2 Histopathologic findings of malignant fibrous histiocytoma (A & B; ×40 & ×100, HE stain) Highly pleomorphic spindle shaped cells are observed in cellular tumor tissue. The tumor shows broad myxoid tissue (arrow) abutting cellular area (A) and fascicular pattern of pleomorphic spindle shaped cells (B).

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  Fig 3 PET-CT findings. Intense F-18 FDG accumulation (arrow) in subareolar and lower lateral portion of right breast (A) and several focal FDG uptake (arrow) in right axilla (B) are observed.

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  Fig 4 The mastectomy specimen. A relatively well circumscribed ovoid mass (arrow) is located beneath skin, which is 3.0×2.5 cm in size and has yellowish to pale gray myxoid and soft cut surface with focal hemorrhage.

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  Fig 5 Immunohistochemical staining of CD68 (×400). The tumor is positive for CD68.

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