J Korean Soc Radiol.  2013 Oct;69(4):307-310. 10.3348/jksr.2013.69.4.307.

Post-Radiation Malignant Fibrous Histiocytoma Following Treatment of Breast Cancer: A Case Report with Imaging Findings

• Min JW
• Lee WA
• Kim YM

• KMID: 2041952
• DOI: http://doi.org/10.3348/jksr.2013.69.4.307

Abstract

Post-radiation malignant fibrous histiocytoma (MFH) of the breast is extremely rare. We report a case of post-radiation MFH that presented a rapidly growing mass in a 52-year-old woman who underwent breast-conserving therapy and adjuvant whole breast irradiation 6 years ago. To the best of our knowledge, only one case of primary MFH of the female breast have been reported with sonographic findings. We analyzed the sonographic and MRI findings with correlative histopathologic features, and then confirmed with surgical excision.

MeSH Terms

Breast
Female
Histiocytoma, Malignant Fibrous
Humans
Middle Aged

Figure

• 

  Fig. 1 A 52-year-old woman with a rapidly growing mass in her right lower breast near the inframammary fold. A. Ultrasonography reveal a 6 × 2.8 cm oval, circumscribed mass with a complex echogenicity at the 6 o'clock position. B. Elongated septated cystic area can be seen at the upper portion of mass (arrows). C. On color Doppler sonography, there is some vascular flow within the mass. D. A sagittal, fat-saturated, T2-weighted MR image shows an approximately 6 cm mass with high signal intensity, and peripheral portion of the mass showed avidly high signal intensity, which suggested cystic area (arrows). E. A post-contrast fat-suppressed T1 weighted MR axial image demonstrate a inhomogeneous enhancing solid tumor with surrounding non-enhancing cystic area invading the pectoralis major muscle at the right lower inframammary fold area (arrows). F. A yellow solid tumor was totally excised along with the pectoralis muscle and ribs. G. Microscopic features consisting of plump spindle cells and pleomorphic cells with mitotic activity (hematoxyline and eosin stain, original magnification × 200). H. Immunohistochemical staining demonstrating diffuse cytoplasmic positivity of tumor cells (Immunohistochemistry, original magnification × 200).

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