J Asthma Allergy Clin Immunol.
2001 Dec;21(6):1206-1210.
A case of Sulfone syndrome hypersensitivity associated with dapsone
- Affiliations
-
- 1Department of Internal Medicine, Sun General Hospital, Dae-Jeon, Korea. djna@sunhospital.com
- 2Department of Clinical Pathology, Sun General Hospital, Dae-Jeon, Korea.
Abstract
- Sulfone hypersensitivity syndrome, which is characterized by fever, skin rash, hemolytic anemia, atypical lymphocytosis, and acute hepatic injury, is a potentially fatal variant of dapsone hypersensitivity. A 62-year-old woman with a history of arthralgia developed sulfone syndrome while receiving dapsone 100 mg/day for 20 days. Fever, malaise, prominent rashes, hepatitis, eosinophilia and hemolytic anemia developed and she which required hospitalization. The patient's symptoms reversed following discontinuation of dapsone and administration of steroid (0.5 mg/kg). A case of sulfone syndrome and a brief review of the literature were presented.
