Allergy.
1995 Dec;15(4):650-657.
A case of sulfone syndrome
Abstract
- Sulfone syndrome, which is characterized by fever, skin rash, hemolytic anemia, and acute(rarely fulminant) hepatic injury, is a potentially fatal variants of dapsone hypersensitivity. This syndrome is uncommon but is occuring with increasing frequency. A 19-year-old woman who had taken dapsone for 1 month for the purpose of treating facial acne vulgaris suddenly developed fever, mobiliform skin rashes, hemolytic anemia, hepatitis, and jaundice. There were no other attributable causes of hepatitis. Use of oral steroid(prednisolone 40mg/day) and conservative treatment resulted in almost complete resolution of symptoms and signs, and laboratory data in 8 weeks. We believe that dapsone was a causal factor of this patient's peculiar clinical manifestations. We herein report a case of the "sulfone syndrome" with a review of the literature.
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