Korean J Physiol Pharmacol.
2004 Jun;8(3):129-132.
Interhemispheric Modulation on Afferent Sensory Transmission to the Ventral Posterior Medial Thalamus by Contralateral Primary Somatosensory Cortex
- Affiliations
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- 1Department of Dental Pharmacology, College of Medicine, Kyungpook National University, Daegu 702-412, Korea. bjchoi@knu.ac.kr
- 2Department of Oral Anatomy, College of Medicine, Kyungpook National University, Daegu 702-412, Korea.
- 3College of Dentistry, College of Medicine, Kyungpook National University, Daegu 702-412, Korea.
- 4Department of Pharmacology, College of Medicine, Kyungpook National University, Daegu 702-412, Korea.
- 5Department of Physiology, College of Medicine, Hallym University, Chunchon 200-702, Korea.
Abstract
- Single unit responses of the ventral posterior medial (VPM) thalamic neurons to stimulation were monitored in anesthetized rats during activation of contralateral primary somatosensory (SI) cortex by GABA antagonist. The temporal changes of afferent sensory transmission were quantitatively analyzed by poststimulus time histogram (PSTH). Mainly, afferent sensory transmission to VPM thalamus was facilitated (15 neurons of total 23) by GABA antagonist (bicuculline) applied to contralateral cortex, while 7 neurons were suppressed. However, when ipsilateral cortex was inactivated by GABA agonist, musimol, there was significant suppression of afferent sensory transmission of VPM thalamus. This suppressed responsiveness by ipsilateral musimol was not affected by bicuculline applied to contralateral cortex. These results suggest that afferent transmission to VPM thalamus may be subjected to the interhemispheric modulation via ipsilateral cortex during inactivation of GABAergic neurons in contralateral SI cortex.
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