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Effect of diazepam on the oxytocin induced contraction of the isolated rat uterus

Park YK, Lee SH, Kwon OC, Ha JH, Lee KY, Kim WJ

This study was designed to investigate the effect of diazepam on the spontaneous contraction and oxytocin induced contraction of the isolated rat uterus. Female rat (Sprague-Dawley) pretreated with oophorectomy and...
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Are Spinal GABAergic Elements Related to the Manifestation of Neuropathic Pain in Rat?

Lee J, Back SK, Lim EJ, Cho GC, Kim MA, Kim HJ, Lee MH, Na HS

Impairment in spinal inhibition caused by quantitative alteration of GABAergic elements following peripheral nerve injury has been postulated to mediate neuropathic pain. In the present study, we tested whether neuropathic...
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Interhemispheric Modulation on Afferent Sensory Transmission to the Ventral Posterior Medial Thalamus by Contralateral Primary Somatosensory Cortex

Jung SC, Choi IS, Cho JH, Kim JH, Bae YC, Lee MG, Shin HC, Choi BJ

  • KMID: 2285296
  • Korean J Physiol Pharmacol.
  • 2004 Jun;8(3):129-132.
Single unit responses of the ventral posterior medial (VPM) thalamic neurons to stimulation were monitored in anesthetized rats during activation of contralateral primary somatosensory (SI) cortex by GABA antagonist. The...
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Pharmacology of Intracisternal or Intrathecal Glycine, Muscimol, and Baclofen in Strychnine-induced Thermal Hyperalgesia of Mice

Lee IO, Son JK, Lim ES, Kim YS

Glycine and gamma-aminobutyric acid (GABA) are localized and released by the same interneurons in the spinal cord. Although the effects of glycine and GABA on analgesia are well known, little...
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Loss of the Spinal GABAergic System Is Involved in Chronic Central Pain Following a Spinal Cord Injury; Behavioral and Electrophysiological Evidences

Gwak YS, Shim B, Yoon DM, Nam TS, Paik KS, Leem JW

BACKGROUND: Allodynia, hyperalgesia, and spontaneous pain are symptoms characterized by chronic central pain which was frequently observed following a spinal cord injury (SCI). However, the underlying mechanism has not been...
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Blockade of the Subthalamo-nigral Pathway Prevents the Motor Component of Pilocarpine Induced Generalized Convulsive Seizure in Rats

Choi JY, Kim HS, Kim YI, Park SM, Lee KS, Kim BS

  • KMID: 2186048
  • J Korean Neurol Assoc.
  • 2000 Mar;18(2):192-198.
BACKGROUND: The substantia nigra pars reticulata is a critical site for the control of epileptic seizures. The potentiation of the inhibitory gamma-amino butyric acid (GABA) ergic input from the striatum...
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Morphine-induced Modulation of Nociceptive Spinal Dorsal Horn Neuronal Activities after Formalin-induced Inflammatory Pain

Park JM, Li KW, Jung SJ, Kim J, Kim SJ

  • KMID: 2285313
  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):77-86.
In this study, we examined the morphine-induced modulation of the nociceptive spinal dorsal horn neuronal activities before and after formalin-induced inflammatory pain. Intradermal injection of formalin induced time-dependent changes in...
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